Description

2-Oxa-5-Azabicyclo[2.2.1]Heptane-5-Carboxylic Acid, 1,1-Dimethylethyl Ester, (1S,4S)- is a high-purity, stereochemically defined bicyclic heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key chiral intermediate for constructing complex molecular architectures with precise three-dimensional control, a critical requirement in modern pharmaceutical development. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process chemistry of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral targets.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of novel drug candidates, especially those requiring rigid, bicyclic scaffolds.
• Asymmetric Synthesis: Used as a starting material or advanced intermediate in catalytic asymmetric reactions to introduce stereogenic centers.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing focused libraries of compounds for structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for potential APIs under Good Manufacturing Practice (GMP) guidelines.
• Ligand & Catalyst Development: The structural motif can be incorporated into novel chiral ligands or organocatalysts for enantioselective transformations.
• Chemical Biology Probes: Useful for creating molecular probes to study biological pathways and enzyme functions.

Basic Information

Item	Detail
Product Name	2-Oxa-5-Azabicyclo[2.2.1]Heptane-5-Carboxylic Acid, 1,1-Dimethylethyl Ester, (1S,4S)-
CAS No.	905306-11-8
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	(1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptane-5-carboxylic acid tert-butyl ester; tert-Butyl (1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate; (1S,4S)-5-Boc-2-oxa-5-azabicyclo[2.2.1]heptane; (1S,4S)-N-Boc-2-oxa-5-azabicyclo[2.2.1]heptane; (1S,4S)-endo-N-Boc-2-oxa-5-azabicyclooctane; (1S,4S)-Bicyclic proline derivative Boc-protected; (1S,4S)-5-(tert-Butoxycarbonyl)-2-oxa-5-azabicyclo[2.2.1]heptane
EINECS	Contact for details

Quality Control

Our 2-Oxa-5-Azabicyclo[2.2.1]Heptane-5-Carboxylic Acid, 1,1-Dimethylethyl Ester, (1S,4S)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral excess, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.