Description

2-Amino-4-(4-fluorophenyl)-5-methylthiophene-3-carboxamide is a high-purity, fluorinated thiophene derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key synthetic intermediate in the development of novel active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate its unique fluorinated heterocyclic scaffold into new molecular entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the fluorophenyl and thiophene moieties contribute to biological activity.
• Material Science: Serves as a monomer or functional component in the synthesis of specialty polymers, organic semiconductors, and non-linear optical (NLO) materials.
• Chemical Biology & Proteomics: Employed as a scaffold for designing molecular probes, enzyme inhibitors, and tool compounds for biological pathway analysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production of client-specific target molecules.

Basic Information

Product Name	2-Amino-4-(4-fluorophenyl)-5-methylthiophene-3-carboxamide
CAS No.	905011-31-6
Molecular Formula	C12H11FN2OS
Molecular Weight	250.29 g/mol
Synonyms	2-Amino-4-(4-fluorophenyl)-5-methyl-3-thiophenecarboxamide; 5-Methyl-2-amino-4-(4-fluorophenyl)thiophene-3-carboxamide; 4-(4-Fluorophenyl)-2-amino-5-methylthiophene-3-carboxylic acid amide; 905011-31-6; AKOS BRN 0978; 2-Amino-4-(p-fluorophenyl)-5-methylthiophene-3-carboxamide; Thiophene-3-carboxamide, 2-amino-4-(4-fluorophenyl)-5-methyl-
EINECS	Contact for details

Quality Control

Our 2-Amino-4-(4-fluorophenyl)-5-methylthiophene-3-carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our standard grade meets typical research and development specifications, with custom purity levels (e.g., >98%, >99%) available to support your project from discovery through to pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.