Description

1H-Indole, 1-Methyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, functionalized indole derivative featuring a pinacol boronate ester group. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and material science sectors for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key boronic ester reagent for creating carbon-carbon bonds in the synthesis of novel drug candidates and organic electronic materials.
• Pharmaceutical Intermediate: Core building block for the development of active pharmaceutical ingredients (APIs), particularly those with indole-based structures targeting neurological and oncological pathways.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides that require specific, functionalized heterocyclic components.
• Material Science Research: Employed in the synthesis of organic semiconductors, ligands for catalysts, and novel polymers with tailored electronic properties.
• Chemical Biology & Medicinal Chemistry: Serves as a probe or precursor in the discovery of enzyme inhibitors and receptor modulators.
• Custom Synthesis & Contract Manufacturing: A pivotal starting material for custom synthesis projects requiring precise functionalization at the 7-position of the indole ring.

Basic Information

Product Name	1H-Indole, 1-Methyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	903499-35-4
Molecular Formula	C15H20BNO2
Molecular Weight	257.14 g/mol
Synonyms	1-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-indole; 1-Methyl-1H-indole-7-boronic acid pinacol ester; 1-Methyl-7-(pinacolboryl)indole; 7-Borono-1-methylindole pinacol ester; 1-Methylindole-7-boronic acid pinacol ester; N-Methyl-7-indoleboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of this specialty boronate ester adheres to stringent quality protocols. Every batch undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 11B), and GC/MS, to ensure identity, purity, and the absence of critical impurities. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all relevant specifications. Our quality management system is designed to support cGMP requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent hydrolysis of the boronate ester functionality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.