Description

Ethyl 5-Chloro-3-(trifluoromethyl)-1H-indole-2-carboxylate is a high-value, multi-functional indole derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique molecular architecture, featuring both chloro and trifluoromethyl substituents on the indole core, makes it indispensable for constructing complex molecules with tailored biological and physical properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in oncology, neurology, and anti-inflammatory research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport layers.
• Chemical Biology Probes: Utilized in the design of fluorescent tags and molecular probes for studying biological processes and enzyme activity.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up production under cGMP (current Good Manufacturing Practice) for clinical trial materials.

Basic Information

Product Name	Ethyl 5-Chloro-3-(trifluoromethyl)-1H-indole-2-carboxylate
CAS No.	902772-08-1
Molecular Formula	C₁₂H₉ClF₃NO₂
Molecular Weight	291.65 g/mol
Synonyms	5-Chloro-3-(trifluoromethyl)-1H-indole-2-carboxylic acid ethyl ester; Ethyl 5-chloro-3-(trifluoromethyl)indole-2-carboxylate; 1H-Indole-2-carboxylic acid, 5-chloro-3-(trifluoromethyl)-, ethyl ester; 902772-08-1; 5-Chloro-3-trifluoromethylindole-2-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fine chemical intermediates. Production of Ethyl 5-Chloro-3-(trifluoromethyl)-1H-indole-2-carboxylate is monitored through in-process controls and final release testing via advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch. Our quality system supports development from milligram to kilogram scale, ensuring consistency and reliability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.