Description

2-tert-Butyl-5-Fluoro-1H-Indole is a high-purity, fluorinated indole derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel pharmaceuticals and agrochemicals where the tert-butyl and fluoro substituents impart specific steric and electronic properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functional unit in the development of advanced organic electronic materials and specialty polymers.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Catalyst Ligand Development: The indole core can be functionalized to create novel ligands for transition metal catalysis.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry and for custom synthesis projects in CROs (Contract Research Organizations).

Basic Information

Product Name	2-tert-Butyl-5-Fluoro-1H-Indole
CAS No.	900640-44-0
Molecular Formula	C₁₂H₁₄FN
Molecular Weight	191.25 g/mol
Synonyms	5-Fluoro-2-tert-butyl-1H-indole; 2-(tert-Butyl)-5-fluoro-1H-indole; 5-Fluoro-2-(1,1-dimethylethyl)-1H-indole; 2-tert-Butyl-5-fluoroindole; 900640-44-0; 5-Fluoro-2-tert-butylindole; 2-(tert-Butyl)-5-fluoroindole
EINECS	Contact for details

Quality Control

Our 2-tert-Butyl-5-Fluoro-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.