Description

5-(Trifluoromethyl)-1,3-Thiazole-4-Carboxylic Acid is a high-value, multifunctional heterocyclic building block characterized by its trifluoromethyl-substituted thiazole core. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability, lipophilicity, and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiazole ring.
• Material Science Research: Serves as a precursor for functionalized ligands, organic semiconductors, and specialty polymers.
• Chemical Biology & Proteomics: Employed as a building block for designing enzyme inhibitors, probes, and molecular tags.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and production of client-specific target molecules.

Basic Information

Product Name	5-(Trifluoromethyl)-1,3-Thiazole-4-Carboxylic Acid
CAS No.	900530-68-9
Molecular Formula	C5H2F3NO2S
Molecular Weight	197.14 g/mol
Synonyms	4-Thiazolecarboxylic acid, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-4-thiazolecarboxylic acid; 5-Trifluoromethyl-1,3-thiazole-4-carboxylic acid; 5-Trifluoromethylthiazole-4-carboxylic acid; 900530-68-9; 4-Carboxy-5-(trifluoromethyl)thiazole; 5-(Trifluoromethyl)-1,3-thiazole-4-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 5-(Trifluoromethyl)-1,3-Thiazole-4-Carboxylic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and residual solvents. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.