Description

2-Methyl-5-(Trifluoromethoxy)-1H-Indole is a high-value, multi-functional indole derivative characterized by its unique trifluoromethoxy substituent. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry, prized for its ability to impart desirable properties to target molecules. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Serves as a core structure for creating novel pesticides and herbicides with enhanced efficacy and environmental profiles.
• Material Science Research: Used in the development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic system.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create specialized ligands for catalytic processes.
• Fluorine Chemistry Building Block: Provides a source of the trifluoromethoxy group for introducing fluorine atoms into complex molecules to modulate their lipophilicity, metabolic stability, and bioavailability.

Basic Information

Product Name	2-Methyl-5-(Trifluoromethoxy)-1H-Indole
CAS No.	900182-99-2
Molecular Formula	C10H8F3NO
Molecular Weight	215.17 g/mol
Synonyms	5-(Trifluoromethoxy)-2-methyl-1H-indole; 2-Methyl-5-(trifluoromethoxy)indole; 2-Methyl-5-trifluoromethoxyindole; 1H-Indole, 2-methyl-5-(trifluoromethoxy)-; 900182-99-2; 5-Trifluoromethoxy-2-methylindole
EINECS	Contact for details

Quality Control

Our production of 2-Methyl-5-(Trifluoromethoxy)-1H-Indole adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity and potency. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment. We support development and scale-up with custom synthesis and analytical method development to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider holding under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.