Description

4-((Trimethylsilyl)Ethynyl)-1H-Pyrazole is a high-value organosilicon building block featuring a reactive ethynyl group protected by a trimethylsilyl (TMS) moiety. This compound matters as a versatile synthon in modern organic synthesis, enabling efficient cross-coupling and click chemistry reactions for constructing complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and scalable production of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the pyrazole core and ethynyl functionality contribute to biological activity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers, dendrimers, and advanced organic frameworks.
• Ligand and Catalyst Development: Employed to create novel pyrazole-based ligands for transition metal catalysis and organometallic chemistry applications.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules and bioconjugates for proteomics and cellular imaging studies via bioorthogonal reactions.
• Academic & Industrial R&D: A fundamental research chemical for exploring new synthetic methodologies, including Sonogashira coupling and Huisgen cycloaddition reactions.

Basic Information

Item	Details
Product Name	4-((Trimethylsilyl)Ethynyl)-1H-Pyrazole
CAS No.	900164-93-4
Molecular Formula	C8H14N2Si
Molecular Weight	166.30 g/mol
Synonyms	1H-Pyrazole, 4-[(trimethylsilyl)ethynyl]-; 4-(Trimethylsilylethynyl)-1H-pyrazole; 4-(Trimethylsilylethynyl)pyrazole; 4-(2-Trimethylsilylethynyl)-1H-pyrazole; 4-Ethynyl-1H-pyrazole, trimethylsilyl derivative; TMS-Ethynylpyrazole; (4-Pyrazolyl)ethynyltrimethylsilane
EINECS	Contact for details

Quality Control

Our 4-((Trimethylsilyl)Ethynyl)-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to handle and store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.