Description

1H-Thieno[3,4-D]Imidazole-4-Pentanamide, Hexahydro-n-(2-Mercaptoethyl)-2-Oxo-, (3As,4S,6Ar)- is a complex heterocyclic compound featuring a fused thienoimidazole core, a pentanamide chain, and a terminal mercaptoethyl group. This specific stereochemistry and functional group combination make it a valuable advanced pharmaceutical intermediate for the synthesis of novel active ingredients. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of novel drug candidates, particularly those targeting neurological or metabolic pathways.
• Bioconjugation Reagent: The free thiol (-SH) group enables its use in site-specific conjugation strategies for antibody-drug conjugates (ADCs) or peptide/protein labeling.
• Chemical Biology Probe: Used in medicinal chemistry to explore structure-activity relationships (SAR) and enzyme inhibition studies due to its unique heterocyclic scaffold.
• Precursor for Chiral Catalysts: Serves as a starting material for synthesizing specialized chiral ligands or organocatalysts used in asymmetric synthesis.
• Academic & Industrial R&D: Employed in research laboratories for developing new synthetic methodologies and exploring novel chemical entities.

Basic Information

Product Name	1H-Thieno[3,4-D]Imidazole-4-Pentanamide, Hexahydro-n-(2-Mercaptoethyl)-2-Oxo-, (3As,4S,6Ar)-
CAS No.	99938-68-8
Molecular Formula	C12H19N3O2S2
Molecular Weight	301.43 g/mol
Synonyms	Hexahydro-2-oxo-N-(2-mercaptoethyl)-1H-thieno[3,4-d]imidazole-4-pentanamide; (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide, N-(2-mercaptoethyl)-; Biotin-ethylthiol; Biotin thioethylamine analog; Biotin-SH derivative; Mercaptoethyl biotinamide; Thiol-functionalized biotin analog
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP compliance for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation of the thiol group and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, separate from oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.