Description

(S)-2,3,6,7-Tetrahydro-1H-Pyrazino[2,1-A]Isoquinolin-4(11Bh)-One is a high-purity, chiral heterocyclic compound of significant interest in advanced organic synthesis. This molecule serves as a critical pharmacophore and chiral building block for the development of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, particularly in central nervous system (CNS) and oncology research.
• Asymmetric Synthesis: Utilized as a sophisticated building block for constructing molecules with specific stereochemistry, crucial for drug efficacy and safety.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization to develop new chemical entities.
• Process Chemistry Development: Serves as a starting material or intermediate for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions.
• Chemical Biology Probes: Used in the development of tool compounds for studying biological pathways and target validation.

Basic Information

Product Name	(S)-2,3,6,7-Tetrahydro-1H-Pyrazino[2,1-A]Isoquinolin-4(11Bh)-One
CAS No.	99746-73-3
Molecular Formula	C₁₃H₁₄N₂O
Molecular Weight	214.26 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydro-2,7-naphthyridin-5(6H)-one; (S)-THIQ-Pyrazinone; (S)-Tetrahydroisoquinoline-pyrazinone; (S)-2,3,6,7-Tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one; (S)-4-Oxo-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinoline; (S)-enantiomer of Pyrazinoisoquinolinone; (S)-PZIQ
EINECS	Contact for details

Quality Control

Our production of (S)-2,3,6,7-Tetrahydro-1H-Pyrazino[2,1-A]Isoquinolin-4(11Bh)-One adheres to stringent quality protocols suitable for research and pharmaceutical development. Each batch is characterized and tested to ensure high chiral purity and chemical identity. Comprehensive analytical data, including HPLC for purity and chiral assay, NMR, and MS, are documented. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.