Description

5-Fluoro-1-Phenylsulfonyl-1H-Indole is a high-purity, synthetically valuable fluorinated indole derivative. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in organic synthesis, enabling the introduction of both fluorine and sulfonyl-protected indole motifs. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel bioactive molecules, including kinase inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Research: Used in developing novel pesticides and herbicides where the fluorine atom enhances biological activity and metabolic stability.
• Material Science: Serves as a precursor for specialty polymers and advanced organic electronic materials.
• Chemical Synthesis: Versatile reagent for constructing complex heterocyclic systems via cross-coupling and functional group transformations.
• Bioconjugation & Probe Development: Useful in creating fluorescent probes or affinity labels for biochemical and diagnostic applications.

Basic Information

Product Name	5-Fluoro-1-Phenylsulfonyl-1H-Indole
CAS No.	99532-44-2
Molecular Formula	C14H10FNO2S
Molecular Weight	275.30 g/mol
Synonyms	1H-Indole, 5-fluoro-1-(phenylsulfonyl)-; 5-Fluoro-1-(phenylsulfonyl)indole; 1-(Phenylsulfonyl)-5-fluoroindole; 5-Fluoro-1-(benzenesulfonyl)indole; 5-Fluoroindole-1-sulfonic acid phenyl ester; 5-Fluoro-1H-indole, 1-(phenylsulfonyl)- derivative; 99532-44-2
EINECS	Contact for details

Quality Control

Our 5-Fluoro-1-Phenylsulfonyl-1H-Indole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide full traceability and detailed Certificates of Analysis (COA) upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.