Description

n-Nitrosopiperidine-D4 is a stable isotope-labeled analog of n-nitrosopiperidine, a nitrosamine compound. This deuterated standard is critical for ensuring accurate and reliable analytical results in sensitive detection methods. It is primarily utilized by analytical laboratories and research institutions in the pharmaceutical, food safety, and environmental monitoring sectors for method development, validation, and quality control.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference in LC-MS/MS and GC-MS analysis for nitrosamine impurity testing.
• Pharmaceutical Impurity Profiling: Essential for the detection, identification, and quantification of genotoxic nitrosamine impurities in active pharmaceutical ingredients (APIs) and drug products to meet regulatory requirements (e.g., FDA, EMA).
• Food and Beverage Safety Testing: Employed in the analysis of nitrosamines in processed foods, cured meats, and alcoholic beverages to ensure consumer safety and compliance with food standards.
• Environmental Analysis: Applied in monitoring nitrosamine levels in water, soil, and industrial waste as part of environmental health and safety assessments.
• Metabolic and Toxicological Studies: Serves as a tracer in research to understand the absorption, distribution, metabolism, and excretion (ADME) of nitrosopiperidine.
• Method Development and Validation: A key component for developing robust, sensitive, and specific analytical methods in compliance with ICH Q2(R1) guidelines.
• Quality Control (QC) and Assurance: Used in routine QC laboratories to calibrate instruments and verify the accuracy of testing procedures for nitrosamine contaminants.

Basic Information

Product Name	n-Nitrosopiperidine-D4
CAS No.	99389-11-4
Molecular Formula	C5H6D4N2O
Molecular Weight	116.17 g/mol
Synonyms	Piperidine-2,2,6,6-d4, 1-nitroso-; Deuterated N-Nitrosopiperidine; N-Nitrosopiperidine-d4; 1-Nitrosopiperidine-d4; Nitrosopiperidine (deuterated); N-NP-d4; [2H4]-N-Nitrosopiperidine; Perdeuterated N-Nitrosopiperidine
EINECS	Contact for details

Quality Control

Our n-Nitrosopiperidine-D4 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic enrichment and chemical purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and isotopic abundance is provided to ensure traceability and support your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange liquid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.