Description

2-(trans-4-Hydroxycyclohexyl)-1H-Isoindole-1,3(2H)-Dione is a versatile and high-value organic intermediate featuring a phthalimide core substituted with a trans-4-hydroxycyclohexyl group. This compound matters for its role as a key building block in the synthesis of complex molecules, particularly in pharmaceutical research and development. Industries that need it include pharmaceutical manufacturers, advanced material scientists, and agrochemical R&D teams seeking to incorporate specific stereochemistry and functional groups into their target compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting neurological and metabolic pathways.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, where the hydroxycyclohexyl moiety can influence biological activity and selectivity.
• Liquid Crystal & Advanced Material Research: Serves as a building block for creating novel organic compounds used in liquid crystal displays (LCDs) and other functional materials.
• Polymer Modification: Acts as a monomer or additive to impart specific thermal or mechanical properties to specialty polymers and resins.
• Organic Synthesis & Chemical Research: A valuable reagent for academic and industrial chemists exploring new synthetic methodologies and constructing complex molecular architectures.
• Peptidomimetics & Bioactive Molecule Design: The phthalimide group is a common motif in the design of protease inhibitors and other bioactive compounds, making this a useful intermediate.

Basic Information

Product Name	2-(trans-4-Hydroxycyclohexyl)-1H-Isoindole-1,3(2H)-Dione
CAS No.	99337-98-1
Molecular Formula	C14H15NO3
Molecular Weight	245.27 g/mol
Synonyms	trans-4-Hydroxycyclohexyl Phthalimide; 2-(trans-4-Hydroxycyclohexyl)isoindoline-1,3-dione; 1,3-Dioxo-2-(trans-4-hydroxycyclohexyl)isoindoline; 2-(4-Hydroxycyclohexyl)-1H-isoindole-1,3(2H)-dione (trans-); N-(trans-4-Hydroxycyclohexyl)phthalimide; Phthalimide, N-(trans-4-hydroxycyclohexyl)-; 99337-98-1
EINECS	Contact for details

Quality Control

Our 2-(trans-4-Hydroxycyclohexyl)-1H-Isoindole-1,3(2H)-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm the trans configuration, and standard identification tests. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
trans-Isomer Content (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.