Description

3-[(10,11-Dihydro-5H-Dibenzo[A,D]Cyclohepten-5-Yl)Oxy]-8,8-Dimethyl-8-Azoniabicyclo[3.2.1]Octane is a high-purity, complex organic salt of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or active pharmaceutical ingredient (API) for the synthesis of novel therapeutic agents targeting the central nervous system. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of next-generation neurological and psychiatric medications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel psychotropic and neuroactive drug candidates.
• Neurological Research: Used in preclinical studies to investigate mechanisms related to neurotransmitter modulation and receptor activity.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component for developing new chemical entities (NCEs) with potential antidepressant or anxiolytic properties.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.
• Reference Standard: Utilized as an analytical standard for method development, validation, and quality control in pharmaceutical laboratories.
• Academic Research: Employed in university and institutional labs for medicinal chemistry programs and structure-activity relationship (SAR) studies.

Basic Information

Product Name	3-[(10,11-Dihydro-5H-Dibenzo[A,D]Cyclohepten-5-Yl)Oxy]-8,8-Dimethyl-8-Azoniabicyclo[3.2.1]Octane
CAS No.	99287-13-5
Molecular Formula	C26H33NO
Molecular Weight	375.55 g/mol
Synonyms	8,8-Dimethyl-3-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy]-8-azoniabicyclo[3.2.1]octane; 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane; Nortriptyline N-Oxide Impurity; Nortriptyline Related Compound; 8-Azoniabicyclo[3.2.1]octane, 3-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy]-8,8-dimethyl-
EINECS	Contact for details

Quality Control

Our 3-[(10,11-Dihydro-5H-Dibenzo[A,D]Cyclohepten-5-Yl)Oxy]-8,8-Dimethyl-8-Azoniabicyclo[3.2.1]Octane is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific client or regulatory standards (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.