Description

Piperidine-4-Thiol Hcl CAS NO 99201-86-2 is a high-purity, versatile heterocyclic building block featuring a thiol group, making it a critical intermediate for advanced synthesis. Its primary value lies in enabling the introduction of sulfur-containing moieties into complex molecular architectures, which is essential for modulating biological activity and material properties. This compound is particularly sought after by pharmaceutical R&D teams for drug discovery, especially in developing central nervous system (CNS) agents and enzyme inhibitors, as well as by agrochemical and material science researchers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in the synthesis of piperidine-based therapeutics for neurological disorders and as protease inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the thiol group can act as a reactive handle or pharmacophore.
• Ligand and Catalyst Preparation: Serves as a precursor for chelating ligands in metal catalysis and coordination chemistry, useful in asymmetric synthesis and industrial catalytic processes.
• Peptide Mimetics and Bioconjugation: Employed in creating peptide analogs and for bioconjugation strategies, leveraging the thiol group for selective coupling reactions (e.g., with maleimides).
• Material Science Research: Investigated as a monomer or additive in the synthesis of specialty polymers and functional materials with unique electronic or adhesive properties.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and molecular tools for studying enzyme function and cellular pathways.

Basic Information

Item	Detail
Product Name	Piperidine-4-Thiol Hcl
CAS No.	99201-86-2
Molecular Formula	C5H12ClNS
Molecular Weight	153.67 g/mol
Synonyms	4-Mercaptopiperidine Hydrochloride; 4-Piperidinethiol Hydrochloride; 4-Thiopicolidine Hydrochloride; Piperidine-4-thiol, hydrochloride; 4-Piperidinol, thio-, hydrochloride; 1-Piperidinethiol, 4-, hydrochloride; NSC 403697
EINECS	Contact for details

Quality Control

Every batch of Piperidine-4-Thiol Hcl is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We provide full traceability and guarantee high purity and consistent batch-to-batch quality suitable for research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent oxidation and moisture absorption. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.