Description

Pyruvic-1-13C Acid (Free Acid) is a stable isotope-labeled derivative of pyruvic acid, where the carbon at the 1-position is the 13C isotope. This product is essential for advanced research and development, providing a critical tracer for elucidating metabolic pathways and reaction mechanisms. It is primarily used by scientists and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries for applications in drug discovery, metabolic flux analysis, and the synthesis of labeled compounds.

Application

• Metabolic Pathway Tracing: As a 13C-labeled substrate in NMR and mass spectrometry studies to track carbon flow in glycolysis, the Krebs cycle, and other biochemical pathways.
• Pharmaceutical Research & Development: Used in the synthesis of isotopically labeled active pharmaceutical ingredients (APIs) and metabolites for pharmacokinetic and pharmacodynamic studies.
• Biochemical Assay Development: Serves as a key reagent in enzymatic assays for pyruvate dehydrogenase, pyruvate carboxylase, and other enzymes.
• Diagnostic Agent Synthesis: A precursor in the production of 13C-labeled diagnostic agents used in breath tests, such as the 13C-urea breath test for *Helicobacter pylori*.
• Nutritional and Sports Science Research: Employed in studies investigating energy metabolism, lactate dynamics, and the effects of supplements.
• Agrochemical Research: Utilized in plant metabolism studies to understand herbicide action and plant stress responses.

Basic Information

Product Name	Pyruvic-1-13C Acid (Free Acid)
CAS No.	99124-30-8
Molecular Formula	C3H4O3 (with 13C at position 1)
Molecular Weight	89.05 g/mol (13C isotopic form)
Synonyms	2-Oxopropanoic-1-13C Acid; α-Ketopropionic-1-13C Acid; Acetylformic-1-13C Acid; Pyroracemic-1-13C Acid; 2-Oxopropionic-1-13C Acid; [1-13C]Pyruvic Acid; 13C1-Pyruvic Acid
EINECS	Contact for details

Quality Control

Our Pyruvic-1-13C Acid (Free Acid) is manufactured under strict quality systems to ensure high isotopic and chemical purity, critical for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C), chemical purity, and identity confirmation. We adhere to relevant industry standards for research chemicals, and custom specifications for GMP-grade material are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation, as the product is easily oxidized. Keep the container in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Isotopic Enrichment (NMR)	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.