Description

Chloroacetic-1-13C Acid CAS NO 1681-52-3 is a stable isotope-labeled derivative of chloroacetic acid, where the carbon-1 position is enriched with the 13C isotope. This precise labeling is critical for advanced analytical and research applications, providing a non-radioactive tracer for mechanistic studies and metabolic pathway analysis. It is an essential building block for pharmaceutical, agrochemical, and biochemical researchers who require high isotopic purity and chemical stability for synthesis, quantification, and diagnostic purposes.

Application

• Pharmaceutical Research & Development: As a 13C-labeled precursor in the synthesis of isotopically labeled active pharmaceutical ingredients (APIs) for pharmacokinetic, metabolic, and bio-distribution studies.
• Analytical Chemistry & Mass Spectrometry: Serves as an internal standard for the accurate quantification of chloroacetic acid and related compounds using GC-MS or LC-MS, improving method precision and reliability.
• Biochemical Tracer Studies: Used to trace metabolic pathways and investigate biochemical reaction mechanisms in plant, microbial, and mammalian systems.
• Agrochemical Research: Employed in the development and environmental fate studies of labeled herbicides and plant growth regulators.
• NMR Spectroscopy: Acts as a valuable probe in nuclear magnetic resonance (NMR) spectroscopy due to the distinct signal of the 13C nucleus, aiding in structural elucidation and dynamics studies.
• Environmental Science: Facilitates research into the degradation pathways, environmental persistence, and ecotoxicology of chlorinated acetic acids.

Basic Information

Product Name	Chloroacetic-1-13C Acid
CAS No.	1681-52-3
Molecular Formula	C13CH2ClCOOH
Molecular Weight	95.49 g/mol
Synonyms	Monochloroacetic-1-13C Acid; 2-Chloroacetic-1-13C Acid; Chloroethanoic-1-13C Acid; (13C)Chloroacetic Acid; [1-13C]-Chloroacetic Acid; MCA-1-13C; 13C-Labeled Chloroacetic Acid; Isotopic Chloroacetic Acid
EINECS	Contact for details

Quality Control

Every batch of Chloroacetic-1-13C Acid is manufactured and analyzed under strict quality protocols to ensure exceptional isotopic and chemical purity. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm isotopic enrichment and chemical identity. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as isotopic purity, chemical purity, and assay. We adhere to cGMP principles for research-grade materials to guarantee consistency and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents. Handle and store in accordance with all applicable local and international regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Isotopic Purity (13C)	≥ 99 atom %
Chemical Purity (HPLC)	≥ 98.0%
Assay	97.0 - 103.0%
Melting Point	60 - 63 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.