Description

(S)-(-)-4-(2-Chlorophenyl)-2-Hydroxy-5,5-Dimethyl-1,3,2-Dioxaphosphorinane 2-Oxide is a high-purity, chiral organophosphorus compound of significant interest in advanced synthetic chemistry. This compound matters as a versatile chiral auxiliary and ligand, enabling the precise control of stereochemistry in the synthesis of complex molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in asymmetric synthesis and catalysis.

Application

• As a chiral ligand in asymmetric metal-catalyzed reactions, including hydrogenation and cross-coupling.
• Utilized as a chiral auxiliary in the stereoselective synthesis of active pharmaceutical ingredients (APIs).
• Key intermediate in the research and development of novel therapeutic agents and agrochemicals.
• Employed in methodology development within academic and industrial organic chemistry laboratories.
• Potential use in the synthesis of chiral phosphonate and phosphate derivatives.

Basic Information

Product Name	(S)-(-)-4-(2-Chlorophenyl)-2-Hydroxy-5,5-Dimethyl-1,3,2-Dioxaphosphorinane 2-Oxide
CAS No.	98674-86-3
Molecular Formula	C11H14ClO4P
Molecular Weight	276.65 g/mol
Synonyms	(S)-4-(2-Chlorophenyl)-2-hydroxy-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide; (S)-(-)-2-Hydroxy-4-(2-chlorophenyl)-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide; (S)-2-Hydroxy-5,5-dimethyl-4-(2-chlorophenyl)-1,3,2-dioxaphosphorinane 2-oxide; (S)-4-(o-Chlorophenyl)-2-hydroxy-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide; (S)-HOCP(O)ClPh; Chiral cyclic chlorophosphite; (S)-HOCPCl
EINECS	Contact for details

Quality Control

Our (S)-(-)-4-(2-Chlorophenyl)-2-Hydroxy-5,5-Dimethyl-1,3,2-Dioxaphosphorinane 2-Oxide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is easily oxidized and should be handled with care to minimize exposure to air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.