Description

(R)-(+)-2-Hydroxy-4-(2-Methoxyphenyl)-5,5-Dimethyl-1,3,2-Dioxaphosphorinane CAS NO 98674-82-9 is a high-purity, chiral organophosphorus compound characterized by its unique cyclic dioxaphosphorinane structure. This compound serves as a valuable chiral building block and ligand precursor in advanced synthetic chemistry, enabling the production of enantiomerically pure substances. It is primarily needed by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel active ingredients and catalysts.

Application

• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand in transition metal-catalyzed reactions for the stereoselective construction of complex molecules.
• Pharmaceutical Intermediate: A key precursor in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Agrochemical Research: Used in the development of novel, chiral herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Catalyst Development: Serves as a precursor for chiral phosphine-phosphite or phosphoramidite ligands used in homogeneous catalysis.
• Material Science: Investigated for the synthesis of chiral polymers or as a modifying agent for surfaces with specific stereochemical properties.
• Academic & Process Chemistry: A valuable tool for methodological studies in organic synthesis and for scaling up enantioselective processes.

Basic Information

Product Name	(R)-(+)-2-Hydroxy-4-(2-Methoxyphenyl)-5,5-Dimethyl-1,3,2-Dioxaphosphorinane
CAS No.	98674-82-9
Molecular Formula	C₁₂H₁₇O₄P
Molecular Weight	256.24 g/mol
Synonyms	(R)-2-Hydroxy-4-(2-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaphosphorinane; (R)-(+)-2-Hydroxy-4-(o-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaphosphorinane; (R)-HMP-Diol Phosphite; (R)-2-Hydroxy-5,5-dimethyl-4-(2-methoxyphenyl)-1,3,2-dioxaphosphorinane; (R)-2-Hydroxy-4-(2-methoxyphenyl)-5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinane; Chiral Dioxaphosphorinane Derivative; (R)-HMP
EINECS	Contact for details

Quality Control

Our (R)-(+)-2-Hydroxy-4-(2-Methoxyphenyl)-5,5-Dimethyl-1,3,2-Dioxaphosphorinane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity and chemical integrity, meeting the stringent requirements for research and process development. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and identity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.