Description

(2R,4R)-5,5-Dimethyl-2-Hydroxy-4-Phenyl-1,3,2-Dioxaphosphorinan 2-Oxide is a high-purity, chiral organophosphorus compound of significant interest in advanced synthetic chemistry. Its primary value lies in its role as a versatile chiral building block and ligand for asymmetric catalysis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel, stereoselective synthetic routes.

Application

• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand in transition metal-catalyzed reactions to induce high enantioselectivity.
• Pharmaceutical Intermediates: A key precursor in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and cardiovascular drugs.
• Catalyst Development: Used in the research and development of novel homogeneous catalysts for industrial-scale asymmetric hydrogenation and cross-coupling reactions.
• Agrochemical Synthesis: Serves as a chiral synthon in the production of advanced, stereospecific herbicides and pesticides.
• Material Science Research: Investigated for the development of chiral functional materials and metal-organic frameworks (MOFs).
• Academic & Industrial R&D: A valuable standard and reagent for method development in stereochemistry and organophosphorus chemistry research.

Basic Information

Product Name	(2R,4R)-5,5-Dimethyl-2-Hydroxy-4-Phenyl-1,3,2-Dioxaphosphorinan 2-Oxide
CAS No.	98674-80-7
Molecular Formula	C11H15O4P
Molecular Weight	242.21 g/mol
Synonyms	(2R,4R)-5,5-Dimethyl-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide; (4R)-5,5-Dimethyl-2-oxido-4-phenyl-1,3,2-dioxaphosphorinane; (2R,4R)-4-Phenyl-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide; Chiral Dioxaphosphorinane Oxide; (R,R)-HPO Derivative; Cyclic Phosphonate Ester; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our (2R,4R)-5,5-Dimethyl-2-Hydroxy-4-Phenyl-1,3,2-Dioxaphosphorinan 2-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and NMR for structural confirmation, to ensure high chemical and optical purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.