Description

(R)-(+)-Indoline-2-Carboxylic Acid is a high-purity chiral building block essential for asymmetric synthesis. This compound matters as a key intermediate in the development of active pharmaceutical ingredients (APIs) and complex organic molecules, where its defined stereochemistry is critical for biological activity. It is primarily needed by pharmaceutical R&D departments, fine chemical manufacturers, and academic research institutions focused on medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of various drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a starting material or auxiliary in catalytic and stoichiometric asymmetric reactions to induce chirality.
• Medicinal Chemistry Research: Serves as a core scaffold for constructing compound libraries in drug discovery programs targeting neurological and cardiovascular diseases.
• Peptidomimetics: Incorporated into peptide analogs to enhance metabolic stability and bioavailability.
• Catalyst and Ligand Development: Employed in the preparation of novel chiral catalysts and ligands for enantioselective transformations.
• Reference Standard: Used as an analytical standard for quality control and method development in chiral analysis.

Basic Information

Product Name	(R)-(+)-Indoline-2-Carboxylic Acid
CAS No.	98167-06-7
Molecular Formula	C9H9NO2
Molecular Weight	163.17 g/mol
Synonyms	(R)-Indoline-2-carboxylic acid; (2R)-2,3-Dihydro-1H-indole-2-carboxylic acid; (R)-(+)-2-Carboxyindoline; D-Indoline-2-carboxylic acid; (+)-(R)-Indoline-2-carboxylic acid; (R)-2-Indolinecarboxylic Acid; (R)-1,2-Dihydroindole-2-carboxylic acid; (R)-2,3-Dihydroindole-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (R)-(+)-Indoline-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.