Description

trans-Stilbene Oxide, [3H] is a tritium-labeled analog of the chiral epoxide, trans-stilbene oxide, serving as a critical radiolabeled tracer in advanced chemical and biochemical research. Its primary value lies in enabling precise metabolic and mechanistic studies, particularly in the investigation of cytochrome P450-mediated epoxidation reactions and the stereoselective metabolism of polycyclic aromatic hydrocarbons. This high-purity, isotopically labeled compound is essential for researchers in pharmaceutical development, toxicology, and environmental science who require definitive tracking of molecular pathways.

Application

• Mechanistic Probe for Cytochrome P450 Enzymes: Used to study the stereochemistry and kinetics of epoxidation reactions catalyzed by various CYP isoforms.
• Metabolic Pathway Tracing: Enables the detailed tracking of the metabolic fate of polycyclic aromatic hydrocarbon (PAH) intermediates in in vitro and in vivo systems.
• Epoxide Hydrolase Substrate: Acts as a specific radiolabeled substrate to assay the activity and stereoselectivity of microsomal epoxide hydrolase.
• Toxicological Research: Facilitates studies on the bioactivation and detoxification pathways of carcinogenic PAH precursors.
• Development of Analytical Methods: Serves as a standard for developing and validating sensitive detection methods, such as LC-MS/MS, for epoxide metabolites.
• Chemical Synthesis Intermediate: Provides a labeled building block for the synthesis of more complex, tracer-labeled molecules for research.

Basic Information

Product Name	trans-Stilbene Oxide, [3H]
CAS No.	98092-12-7
Molecular Formula	C14H10O (tritium label position specified by supplier)
Molecular Weight	~210.2 g/mol (varies with specific activity)
Synonyms	(+/-)-trans-Stilbene Oxide, [3H]; trans-1,2-Diphenyloxirane, [3H]; Tritiated trans-Stilbene Oxide; [3H]-TSO; [3H]-trans-Stilbene Oxide; 1,2-Epoxy-1,2-diphenylethane, [3H]; Racemic trans-Stilbene Oxide, [3H]; Stilbene Oxide, trans-, [3H]
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled trans-Stilbene Oxide, [3H] is manufactured and analyzed under strict quality systems to ensure high chemical, radiochemical, and isomeric purity. Product specifications are confirmed via advanced analytical techniques including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) detailing specific activity, purity, solvent, and analytical chromatograms is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as supplied. Due to its nature as a highly volatile and strictly light-sensitive compound, prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and specific activity. Follow all applicable laboratory safety and radioactive material handling protocols.

Specification

Item	Specification
Appearance	Clear Colorless Solution
Identification (HPLC)	Conforms to Reference Standard
Chemical Purity (HPLC)	≥ 98%
Radiochemical Purity	≥ 97%
Specific Activity	Customizable (e.g., 10-30 Ci/mmol)
Concentration	1.0 mCi/mL (as specified)
Solvent	Toluene or Ethanol (Specified per batch)
Isomeric Purity (trans-)	≥ 99%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.