Description

(1R)-(-)-(1-Aminopropyl)Phosphonic Acid CAS NO 98049-00-4 is a high-purity, chiral organophosphorus compound characterized by its single enantiomer configuration. This compound is a critical chiral building block and intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where stereochemical purity is paramount. It is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing active ingredients with specific biological activities.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in antiviral and osteoporosis treatments.
• Agrochemical Synthesis: Used in the production of chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy and environmental profile.
• Ligand for Catalysis: Serves as a precursor for chiral phosphonate ligands in asymmetric catalysis, enabling highly enantioselective synthetic transformations.
• Biochemical Research: Employed in studies of enzyme inhibition and as a molecular probe to investigate biological pathways involving phosphate mimics.
• Peptidomimetic Chemistry: Incorporated into peptide analogs to enhance stability and modulate biological activity by replacing natural amino acid residues.
• Material Science: A monomer or additive for creating functional polymers with specific chelating or surface-modifying properties.

Basic Information

Product Name	(1R)-(-)-(1-Aminopropyl)Phosphonic Acid
CAS No.	98049-00-4
Molecular Formula	C₃H₁₀NO₃P
Molecular Weight	139.09 g/mol
Synonyms	(R)-1-Amino-1-phosphonopropane; (1R)-1-Aminopropylphosphonic Acid; (-)-(1-Aminopropyl)phosphonic Acid; (R)-1-Aminopropylphosphonic Acid; D-1-Aminopropylphosphonic Acid; (R)-APPA; Phosphonic acid, P-[(1R)-1-aminopropyl]-; (R)-1-Phosphonopropylamine
EINECS	Contact for details

Quality Control

Our (1R)-(-)-(1-Aminopropyl)Phosphonic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure compliance with stringent specifications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided to guarantee reliable and consistent quality for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.