Description

1-Acetyl-4-Iodo-1H-Pyrazole is a high-purity iodinated pyrazole derivative, serving as a versatile and critical building block in advanced organic synthesis. Its value lies in the strategic placement of iodine, which facilitates efficient cross-coupling reactions for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides by acting as a core heterocyclic scaffold.
• Material Science: Serves as a monomer or functionalizing agent in the creation of specialty polymers and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for Suzuki, Stille, and Sonogashira couplings to introduce the pyrazole moiety.
• Chemical Biology & Proteomics: Utilized as a tagging or labeling reagent for studying protein-ligand interactions and cellular processes.
• Ligand Synthesis: Acts as a starting material for creating novel N-heterocyclic carbene (NHC) ligands used in catalysis.

Basic Information

Product Name	1-Acetyl-4-Iodo-1H-Pyrazole
CAS No.	98027-52-2
Molecular Formula	C5H5IN2O
Molecular Weight	236.01 g/mol
Synonyms	1-Acetyl-4-iodopyrazole; 4-Iodo-1H-pyrazole-1-acetamide (misnomer); 4-Iodo-1-acetylpyrazole; 1H-Pyrazole-1-acetamide, 4-iodo-; 1-(4-Iodo-1H-pyrazol-1-yl)ethanone; 1-Acetyl-4-iodo-1H-pyrazole; 98027-52-2 (CAS)
EINECS	Contact for details

Quality Control

Our 1-Acetyl-4-Iodo-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants and maintaining an inert atmosphere to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.