Description

2-Chloro-N,n-Dimethyl-D6-Ethylamine Hcl is a deuterium-labeled isotopologue of a key pharmaceutical intermediate. This compound is crucial for research and development in drug metabolism and pharmacokinetic (DMPK) studies, providing a stable, non-radioactive tracer. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in advanced analytical chemistry and the synthesis of labeled compounds for internal standards and mechanistic investigations.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical, isotopically labeled internal standard in quantitative bioanalytical methods, enhancing accuracy and precision in drug concentration measurements.
• Metabolite Identification & Tracing: Used in drug metabolism studies to trace metabolic pathways and identify metabolites using mass spectrometry.
• Pharmaceutical Intermediate Synthesis: Acts as a building block in the synthesis of more complex deuterated active pharmaceutical ingredients (APIs) and other labeled intermediates.
• Mechanistic Reaction Studies: Employed in chemical and biochemical research to elucidate reaction mechanisms and kinetics through isotopic labeling.
• Reference Material Development: Provides a certified reference material (CRM) for method validation and quality control in analytical laboratories.

Basic Information

Product Name	2-Chloro-N,n-Dimethyl-D6-Ethylamine Hcl
CAS No.	97941-91-8
Molecular Formula	C4D6ClN•HCl
Molecular Weight	144.06 g/mol (for monoisotopic mass)
Synonyms	2-Chloro-N,N-dimethylethan-1-amine-d6 hydrochloride; N,N-Dimethyl-2-chloroethylamine-d6 hydrochloride; Deutero-DMCE hydrochloride; (2-Chloroethyl)dimethylamine-d6 hydrochloride; DMAE-d6 hydrochloride; CD3N(CD3)CH2CH2Cl•HCl; Dimethylaminoethyl chloride-d6 HCl; Ethanamine, 2-chloro-N,N-dimethyl-, hydrochloride-d6
EINECS	Contact for details

Quality Control

Our 2-Chloro-N,n-Dimethyl-D6-Ethylamine Hcl is manufactured under strict quality systems to ensure high isotopic and chemical purity, essential for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity (by HPLC/NMR), and identity confirmation. We adhere to cGMP principles for advanced intermediates to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.