Description

α-Linolenic Acid, Trimethylsilyl Ester is a chemically modified derivative of the essential ω-3 fatty acid, α-linolenic acid (ALA), where the carboxylic acid group is protected as a trimethylsilyl (TMS) ester. This derivatization is a critical analytical and synthetic technique, enhancing the volatility and thermal stability of the fatty acid for precise characterization. It is primarily utilized by research scientists, analytical chemists, and process developers in life sciences and chemical synthesis. The compound serves as a key standard and intermediate for gas chromatography (GC) and mass spectrometry (MS) analysis, as well as in the preparation of specialized lipid derivatives.

Application

• Analytical Reference Standard: Serves as a primary standard for the qualitative and quantitative analysis of α-linolenic acid and related ω-3 compounds via Gas Chromatography (GC) and Gas Chromatography-Mass Spectrometry (GC-MS).
• Derivatization Agent in Metabolomics: Used to prepare volatile derivatives of fatty acids and other carboxylic acids for metabolic profiling and lipidomics studies, improving detection sensitivity and resolution.
• Chemical Synthesis Intermediate: Acts as a protected building block in organic and medicinal chemistry for the synthesis of complex lipids, pharmaceuticals, and bioactive molecules where the carboxylic acid functionality must be temporarily masked.
• Pharmaceutical Research: Employed in the research and development of nutraceuticals and pharmaceuticals targeting cardiovascular health, inflammation, and neurological functions related to ω-3 fatty acids.
• Food & Nutritional Science: Used in the analysis of ω-3 content in food products, dietary supplements, and oils to ensure label claim verification and quality control.
• Material Science Research: Investigated as a precursor or modifier in the development of bio-based polymers and functional materials.

Basic Information

Product Name	α-Linolenic Acid, Trimethylsilyl Ester
CAS No.	97844-13-8
Molecular Formula	C24H46O2Si
Molecular Weight	394.71 g/mol
Synonyms	Linolenic Acid Trimethylsilyl Ester; (9Z,12Z,15Z)-9,12,15-Octadecatrienoic Acid Trimethylsilyl Ester; ALA-TMS; Trimethylsilyl Linolenate; cis,cis,cis-9,12,15-Octadecatrienoic Acid TMS Ester; α-Linolenic Acid TMS Derivative; TMS-ALA; (Z,Z,Z)-9,12,15-Octadecatrienoic Acid Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our α-Linolenic Acid, Trimethylsilyl Ester is produced and handled under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive analytical and research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced for research use, our quality systems are designed to support applications requiring reliable and traceable reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 95.0%
Related Substances (GC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.