Description

4-[(S)-3-[4-(Diphenylmethyl)-1-Piperazinyl]-2-Hydroxypropoxy]-1H-Indole-2-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and complex molecular architecture. This compound is of significant value in the research and development of novel therapeutic agents, particularly those targeting central nervous system (CNS) disorders. It is primarily sought by pharmaceutical companies, biotechnology firms, and advanced research institutions engaged in the synthesis of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of proprietary drug candidates, particularly in the CNS therapeutic area.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in API manufacturing.
• Preclinical Studies: Employed in the preparation of compounds for pharmacological screening and toxicological evaluation.
• Process Chemistry: Utilized in the development and scale-up of efficient synthetic routes for target molecules.

Basic Information

Product Name	4-[(S)-3-[4-(Diphenylmethyl)-1-Piperazinyl]-2-Hydroxypropoxy]-1H-Indole-2-Carbonitrile
CAS No.	97749-21-8
Molecular Formula	C29H30N4O2
Molecular Weight	466.58 g/mol
Synonyms	(S)-4-[3-[4-(Diphenylmethyl)piperazin-1-yl]-2-hydroxypropoxy]-1H-indole-2-carbonitrile; UNII-4V3Y9C5W4P; 4-[(2S)-3-[4-(Diphenylmethyl)-1-piperazinyl]-2-hydroxypropoxy]-1H-indole-2-carbonitrile; 1H-Indole-2-carbonitrile, 4-[(2S)-3-[4-(diphenylmethyl)-1-piperazinyl]-2-hydroxypropoxy]-; 4-[(S)-3-[4-(Benzhydryl)piperazin-1-yl]-2-hydroxypropoxy]-1H-indole-2-carbonitrile
EINECS	Contact for details

Quality Control

Our 4-[(S)-3-[4-(Diphenylmethyl)-1-Piperazinyl]-2-Hydroxypropoxy]-1H-Indole-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the high standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive; ensure the container is kept sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.