Description

trans-5-Trimethylsilyl-2-Penten-4-Yn-1-Ol is a specialized organosilicon building block featuring both an alkyne and a protected alcohol functional group. This unique bifunctional structure makes it a valuable intermediate for constructing complex molecular architectures in advanced organic synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as cross-coupling reactions and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those requiring alkyne or silyl-protected alcohol moieties.
• Agrochemical Research: Used in the development of new pesticides and herbicides where its functional groups enable modular structure-activity relationship (SAR) studies.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and silicon-containing advanced materials.
• Cross-Coupling Reactions: The terminal alkyne group is highly reactive in Sonogashira, Glaser, and other metal-catalyzed coupling reactions to form carbon-carbon bonds.
• Ligand Synthesis: Employed in the preparation of sophisticated ligands for catalysis, leveraging the silyl group for subsequent deprotection and functionalization.
• Academic & R&D: A versatile tool in academic laboratories for methodological development and the synthesis of natural product analogs or molecular probes.

Basic Information

Item	Detail
Product Name	trans-5-Trimethylsilyl-2-Penten-4-Yn-1-Ol
CAS No.	97514-97-1
Molecular Formula	C9H16OSi
Molecular Weight	168.31 g/mol
Synonyms	5-(Trimethylsilyl)-2-penten-4-yn-1-ol; (E)-5-(Trimethylsilyl)pent-2-en-4-yn-1-ol; 2-Penten-4-yn-1-ol, 5-(trimethylsilyl)-, (E)-; TMS-protected propargylic alcohol; (E)-5-(Trimethylsilyl)-2-penten-4-yn-1-ol; Trimethyl[(1E)-1-hydroxy-4-penten-1-yn-3-yl]silane
EINECS	Contact for details

Quality Control

Our trans-5-Trimethylsilyl-2-Penten-4-Yn-1-Ol is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.