Description

5-Nitro-2-Difluoromethyl-1H-Benzimidazole is a high-value, multi-functional heterocyclic building block. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, enabling the introduction of key nitro and difluoromethyl functional groups. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel benzimidazole-based drug candidates, particularly for antiviral, anticancer, and anti-parasitic applications.
• Agrochemical Synthesis: Used in the development of next-generation fungicides and herbicides, where the difluoromethyl group can enhance biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating specialized polymers, ligands, or organic electronic materials with unique properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic routes and scale-up projects.

Basic Information

Product Name	5-Nitro-2-Difluoromethyl-1H-Benzimidazole
CAS No.	97273-25-1
Molecular Formula	C8H5F2N3O2
Molecular Weight	213.14 g/mol
Synonyms	2-(Difluoromethyl)-5-nitro-1H-benzimidazole; 1H-Benzimidazole, 2-(difluoromethyl)-5-nitro-; 5-Nitro-2-difluoromethylbenzimidazole; 97273-25-1; 2-Difluoromethyl-5-nitrobenzimidazole; 5-Nitro-2-(difluoromethyl)-1H-benzimidazole; 5-Nitro-2-difluoromethyl-1H-benzo[d]imidazole
EINECS	Contact for details

Quality Control

Our 5-Nitro-2-Difluoromethyl-1H-Benzimidazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.