Description

[2H6]-Metoprolol CAS NO 96849-43-3 is a stable isotope-labeled analog of the widely used β-blocker metoprolol, where six hydrogen atoms are replaced by deuterium. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is critically needed by pharmaceutical research and development laboratories, clinical research organizations, and forensic toxicology units for applications in drug metabolism studies (DMPK), pharmacokinetic analysis, and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS and GC-MS quantification of metoprolol and its metabolites in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK) studies to track the absorption, distribution, metabolism, and excretion of metoprolol.
• Bioanalytical method development and validation in support of clinical trials and regulatory submissions.
• Forensic and clinical toxicology analysis for accurate measurement of metoprolol concentrations.
• Isotope dilution mass spectrometry (IDMS) for achieving the highest level of measurement certainty.
• Metabolite identification and structural elucidation studies in pharmaceutical research.
• Quality control and assurance in reference material and pharmaceutical manufacturing.

Basic Information

Product Name	[2H6]-Metoprolol
CAS No.	96849-43-3
Molecular Formula	C15H19D6NO3
Molecular Weight	270.40 g/mol
Synonyms	Metoprolol-d6; Deuterated Metoprolol; Metoprolol (hexadeuterated); 1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol-d6; (±)-Metoprolol-d6; Lopressor-d6; Toprol-XL-d6; (RS)-Metoprolol-d6
EINECS	Contact for details

Quality Control

Our [2H6]-Metoprolol is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity, and absence of interfering impurities. We adhere to relevant industry standards for reference materials, and custom synthesis to meet specific purity or isotopic enrichment requirements is available.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.