Description

n-Acetyl-2-Amino-5-Phenyl-D5-Pyridine is a deuterated pyridine derivative, specifically a deuterated isotopologue of n-acetyl-2-amino-5-phenylpyridine, where five hydrogen atoms are replaced by deuterium. This compound is a crucial stable isotope-labeled standard, providing unmatched precision for analytical and research applications requiring high specificity and minimal background interference. It is primarily utilized by pharmaceutical researchers, analytical chemists, and contract research organizations (CROs) engaged in advanced drug metabolism, pharmacokinetic (DMPK) studies, and quantitative mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in bioanalytical method development for drug and metabolite analysis.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracing and quantifying parent drugs and their metabolites in biological matrices during preclinical and clinical studies.
• Isotope Dilution Mass Spectrometry (IDMS): Employed for achieving high-accuracy, precise quantification in complex sample analysis.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products.
• Metabolomics Research: Facilitates the accurate measurement of endogenous and exogenous compounds in systems biology studies.
• Stable Isotope Labeling: Acts as a building block or tracer in the synthesis of more complex labeled compounds for mechanistic studies.

Basic Information

Product Name	n-Acetyl-2-Amino-5-Phenyl-D5-Pyridine
CAS No.	96721-90-3
Molecular Formula	C13H8D5N2O
Molecular Weight	218.28 g/mol
Synonyms	2-Acetamido-5-phenylpyridine-d5; N-(5-Phenylpyridin-2-yl)acetamide-d5; 2-Acetylamino-5-phenylpyridine-d5; Deuterated n-Acetyl-2-Amino-5-Phenylpyridine; [D5]-2-Acetamido-5-phenylpyridine; 5-Phenyl-2-acetamidopyridine-d5; Stable Isotope Labeled 2-AA5PP
EINECS	Contact for details

Quality Control

Our deuterated standards are manufactured under strict quality protocols to ensure exceptional isotopic purity and chemical integrity. Each batch undergoes comprehensive analysis, including NMR (¹H, ²H, ¹³C) for structural and isotopic confirmation and HPLC/UPLC for chemical purity assessment. We provide a detailed Certificate of Analysis (COA) with each shipment, specifying batch-specific data for isotopic enrichment (atom % D), chemical purity, and identity. Our quality system supports compliance with ISO 9001 standards and meets the rigorous demands of GLP/GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry place. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation from moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0% (by ²H NMR or MS)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.