Description

3-Hydroxymethylindole-1-Carboxylic Acid tert-Butyl Ester is a versatile and high-purity indole derivative, serving as a critical protected intermediate in advanced organic synthesis. Its primary value lies in enabling the controlled functionalization of the indole scaffold, which is a privileged structure in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of indole-based drug candidates, including potential kinase inhibitors, serotonin receptor modulators, and anti-cancer agents.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that leverage the indole core structure.
• Organic Synthesis: Serves as a protected precursor for introducing the hydroxymethylindole moiety into more complex molecular architectures under mild conditions.
• Peptide Mimetics & Bioconjugation: The carboxylic acid tert-butyl ester and hydroxymethyl groups provide orthogonal protection strategies for constructing peptide-like molecules or bioconjugates.
• Material Science Research: Potential monomer or precursor for specialty polymers and functional organic materials with specific electronic or photophysical properties.

Basic Information

Product Name	3-Hydroxymethylindole-1-Carboxylic Acid tert-Butyl Ester
CAS No.	96551-22-3
Molecular Formula	C14H17NO3
Molecular Weight	247.29 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester; tert-Butyl 3-(hydroxymethyl)indole-1-carboxylate; 1-Boc-3-(hydroxymethyl)indole; 3-Hydroxymethyl-1H-indole-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)indole; 3-(Hydroxymethyl)-1-indolecarboxylic acid 1,1-dimethylethyl ester; Boc-3-hydroxymethylindole
EINECS	Contact for details

Quality Control

Our 3-Hydroxymethylindole-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.