Description

tert-Butyl 3-bromomethyl-indole-1-carboxylate is a versatile and high-value brominated indole derivative, primarily serving as a key synthetic intermediate in advanced organic synthesis. Its core value lies in the reactive bromomethyl group, which facilitates efficient functionalization and chain elongation, making it indispensable for constructing complex molecular architectures. This compound is critically needed by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), agrochemicals, and novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides that require specific indole scaffolds for bioactivity.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Heck) and nucleophilic substitution reactions to introduce functionalized indole units.
• Material Science Research: Serves as a precursor for creating specialized organic ligands, dyes, and photoactive materials.
• Academic & R&D Laboratories: A valuable reagent for methodological development and exploring new synthetic pathways in heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 3-Bromomethyl-Indole-1-Carboxylate
CAS No.	96551-21-2
Molecular Formula	C14H16BrNO2
Molecular Weight	310.19 g/mol
Synonyms	1-Boc-3-(bromomethyl)indole; tert-Butyl 3-(bromomethyl)-1H-indole-1-carboxylate; 3-(Bromomethyl)-1-[(2-methyl-2-propanyl)oxycarbonyl]-1H-indole; 1H-Indole-1-carboxylic acid, 3-(bromomethyl)-, 1,1-dimethylethyl ester; 3-Bromomethyl-1-Boc-indole; 1-Boc-3-bromomethylindole; Boc-3-bromomethylindole; 96551-21-2
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-bromomethyl-indole-1-carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, NMR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.