Description

Tifluadom Hydrochloride is a synthetic benzodiazepine derivative with high pharmacological specificity. This compound is primarily utilized as a potent and selective research chemical for investigating the kappa opioid receptor (KOR) system and its role in neurological pathways. It serves as a critical tool for pharmaceutical R&D, academic research, and toxicology studies focused on analgesia, addiction, and mood disorders. The product is supplied as a high-purity reference material to ensure reliable and reproducible experimental results.

Application

• Pharmacological Research: A key reference standard for studying the binding affinity and functional activity of kappa opioid receptors (KOR).
• Neuroscience Studies: Used in preclinical models to investigate the mechanisms of analgesia, stress response, and dysphoria associated with KOR activation.
• Drug Discovery & Development: Serves as a lead compound or comparator in the development of novel centrally-acting therapeutic agents.
• Forensic & Toxicology Analysis: Employed as an analytical standard for the identification and quantification of novel psychoactive substances (NPS) in forensic samples.
• Biochemical Assay Development: Used to validate and calibrate in vitro assay systems, including receptor binding and functional cell-based assays.
• Academic Research: Supports university and institutional research into neuropharmacology, receptor biology, and signal transduction.

Basic Information

Product Name	Tifluadom Hydrochloride
CAS No.	96337-50-7
Molecular Formula	C₂₀H₂₀ClFN₂O₂ • HCl
Molecular Weight	405.30 g/mol
Synonyms	Tifluadom HCl; 4'-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one Hydrochloride; 5-(2-Fluorophenyl)-4'-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one Hydrochloride; Tifluadom Monohydrochloride; L-364,718 (obsolete); Kappa Opioid Receptor Agonist Tifluadom HCl; Benzodiazepine Derivative Tifluadom
EINECS	Contact for details

Quality Control

Our Tifluadom Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to relevant standards for research chemicals to guarantee product integrity and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.