Description

Dl-Phenylalanine-Beta,β-D2 CAS NO 96259-02-8 is a deuterium-labeled isotopologue of the amino acid phenylalanine, where two hydrogen atoms at the beta position are replaced with deuterium. This stable isotope-labeled compound is a critical tool for advanced research and analytical applications, providing a non-radioactive tracer for metabolic and pharmacokinetic studies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors who require high-purity, isotopically enriched materials for mass spectrometry, NMR spectroscopy, and drug development.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a crucial quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of phenylalanine and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Used as a stable isotope tracer to investigate amino acid metabolism, protein synthesis rates, and metabolic flux in in vitro and in vivo studies.
• Pharmaceutical Research & Development: Employed in the synthesis of deuterated drug candidates for improved pharmacokinetic profiles (deuterated drugs) and in ADME (Absorption, Distribution, Metabolism, Excretion) studies.
• NMR Spectroscopy: Acts as a probe in nuclear magnetic resonance spectroscopy to elucidate molecular structure, dynamics, and interactions without signal interference from protons.
• Biochemical Research: Utilized in enzymatic studies and as a building block for synthesizing labeled peptides and proteins for specialized research applications.
• Clinical Diagnostics: Potential use in developing advanced assays for monitoring metabolic disorders such as phenylketonuria (PKU).

Basic Information

Product Name	Dl-Phenylalanine-Beta,β-D2
CAS No.	96259-02-8
Molecular Formula	C9H9D2NO2
Molecular Weight	167.20 g/mol (for deuterated form)
Synonyms	DL-Phenylalanine-β,β-d2; (RS)-2-Amino-3-phenylpropionic-3,3-d2 acid; (±)-Phenylalanine-3,3-d2; Phenylalanine-d2 (beta,beta); 2-Amino-3-phenylpropionic-3,3-d2 acid; (DL)-3,3-Dideuteriophenylalanine; Phenylalanine (DL, beta,β-d2); Deuterated DL-Phenylalanine
EINECS	Contact for details

Quality Control

Our Dl-Phenylalanine-Beta,β-D2 is produced and controlled under stringent quality management systems to ensure the high isotopic and chemical purity required for sensitive research applications. Each batch is analyzed to confirm identity, chemical purity, isotopic enrichment (D-incorporation), and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing results from NMR, MS, and HPLC is provided, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure and deuteration pattern
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D (at beta,beta positions)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.