Description

tert-Butyl 3-[(2S)-2-Amino-3-Methoxy-3-Oxopropyl]Indole-1-Carboxylate is a high-purity, chiral indole derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected, stereochemically defined scaffold essential for constructing complex molecules with high enantiomeric purity. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of novel drug candidates, especially for central nervous system (CNS) and oncology targets.
• Peptidomimetic Research: Used to incorporate constrained tryptophan analogs into peptide backbones to enhance stability and bioavailability.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric reactions to introduce indole-based chirality.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) and methyl ester groups allow for orthogonal deprotection in multi-step synthetic sequences.
• Chemical Biology Probes: Utilized in the development of fluorescent or affinity-labeled probes for studying protein-ligand interactions.
• Agrochemical Development: Potential intermediate for creating advanced, chiral crop protection agents with specific modes of action.

Basic Information

Product Name	tert-Butyl 3-[(2S)-2-Amino-3-Methoxy-3-Oxopropyl]Indole-1-Carboxylate
CAS No.	96238-70-9
Molecular Formula	C17H22N2O4
Molecular Weight	318.37 g/mol
Synonyms	1-Boc-3-[(S)-2-Amino-2-carbomethoxyethyl]indole; (S)-1-(tert-Butoxycarbonyl)-3-(2-amino-2-methoxycarbonylethyl)indole; tert-Butyl (S)-3-(2-amino-2-methoxy-2-oxoethyl)-1H-indole-1-carboxylate; Boc-L-Trp(OMe)-OH; Methyl (S)-1-Boc-2,3-dihydro-3-tryptophanate; 1-N-Boc-3-[(S)-α-Amino-β-methoxycarbonylethyl]indole; L-Tryptophan, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-[(2S)-2-Amino-3-Methoxy-3-Oxopropyl]Indole-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.