Description

5-Methoxytryptamine-Alpha,Alpha,Beta,β-D4 is a stable isotope-labeled analog of the endogenous neurotransmitter and neuromodulator 5-methoxytryptamine. This deuterated compound is a critical tool for quantitative analysis in life science research, providing unmatched precision and reliability in mass spectrometry-based assays. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in metabolomics, pharmacokinetic studies, and neurochemical pathway analysis.

Application

• Internal Standard for LC-MS/MS: Serves as a quantitative internal standard for the accurate measurement of endogenous 5-methoxytryptamine in complex biological matrices like plasma, serum, and cerebrospinal fluid.
• Metabolomics Research: Enables precise tracking and quantification in studies of tryptamine and melatonin metabolic pathways.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies for drugs targeting serotonergic systems.
• Neurochemical Analysis: Facilitates research into the role of trace amines and their receptors in neurological function and disorders.
• Biomarker Discovery and Validation: Critical for developing and validating high-sensitivity clinical assays for diagnostic purposes.
• Quality Control in Pharmaceutical Manufacturing: Can be employed as a reference standard in the QC of APIs or formulations related to serotonin pathway modulators.

Basic Information

Product Name	5-Methoxytryptamine-Alpha,Alpha,Beta,β-D4
CAS No.	96236-05-4
Molecular Formula	C₁₁H₁₀D₄N₂O
Molecular Weight	194.27 g/mol
Synonyms	5-Methoxy-D4-tryptamine; 5-MeOT-d4; [2,2,3,3-D4]-5-Methoxytryptamine; 5-Methoxytryptamine-α,α,β,β-d4; 3-(2-Aminoethyl)-5-methoxyindole-d4; 5-MT-d4; 5-Methoxy-1H-indole-3-ethanamine-d4; NSC 113019-d4
EINECS	Contact for details

Quality Control

Our 5-Methoxytryptamine-Alpha,Alpha,Beta,β-D4 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-enrichment), chemical purity by HPLC, and confirmation of structure. We adhere to relevant industry standards for reference materials to guarantee reliable and reproducible performance in your sensitive analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.