Description

Gramine-Alpha,α-D2 is a deuterated derivative of the indole alkaloid gramine, specifically labeled at the alpha positions. This compound is a crucial stable isotope-labeled standard, providing unmatched value for quantitative analysis and metabolic pathway tracing in research. It is primarily required by analytical chemists and researchers in the pharmaceutical, agrochemical, and life science sectors for use in mass spectrometry, NMR spectroscopy, and as an internal standard for pharmacokinetic studies.

Application

• Internal Standard for Mass Spectrometry (MS): Essential for accurate quantification of gramine and related metabolites in complex biological matrices using LC-MS or GC-MS.
• Metabolic Pathway Tracing: Used in deuterium labeling studies to investigate the biosynthesis, degradation, and metabolic fate of indole alkaloids in plants and biological systems.
• NMR Spectroscopy: Serves as a valuable probe in nuclear magnetic resonance studies due to the distinct signal of deuterium, aiding in structural elucidation and dynamic analysis.
• Pharmaceutical Research: Employed in drug discovery and development for precise pharmacokinetic (PK) and pharmacodynamic (PD) studies of gramine-based compounds.
• Quality Control & Method Development: Used in analytical laboratories to develop and validate robust testing methods for gramine in raw materials and finished products.
• Biochemical Research: Facilitates studies on enzyme mechanisms and interactions where gramine acts as a substrate or inhibitor.

Basic Information

Product Name	Gramine-Alpha,α-D2
CAS No.	95415-84-2
Molecular Formula	C11H14D2N2
Molecular Weight	178.26 g/mol
Synonyms	3-(Dimethylaminoethyl)indole-d2; 1-(1H-Indol-3-yl)-N,N-dimethylmethanamine-d2; Gramine-d2; (3-(2-Dimethylaminoethyl)indole)-alpha,α-d2; Deuterated Gramine; D2-Gramine; Donaxine-d2
EINECS	Contact for details

Quality Control

Our Gramine-Alpha,α-D2 is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and purity by HPLC. We support research and development with materials that meet the exacting standards required for spectroscopic and mass spectrometric applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.