Description

1-(2-Bromoethyl)-1H-Pyrrole-2,5-Dione is a versatile brominated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its bifunctional reactivity, featuring both an electrophilic bromoethyl handle and the electrophilic carbonyls of the maleimide ring, enabling it to act as a key linker or precursor in the construction of complex molecules. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications ranging from medicinal chemistry to polymer modification.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting specific biological pathways via maleimide-based conjugation.
• Bioconjugation & Probe Synthesis: Used to functionalize proteins, peptides, or antibodies for drug delivery systems, diagnostic assays, and biochemical probes due to its reactivity with thiol groups.
• Polymer & Material Science: Acts as a cross-linking agent or monomer for creating specialty polymers, hydrogels, and functionalized surfaces with tailored properties.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, or plant growth regulators by introducing the maleimide pharmacophore.
• Chemical Biology Tool: Utilized to create activity-based probes for studying enzyme function and protein-protein interactions.
• Organic Synthesis Building Block: Facilitates various C-N and C-C bond-forming reactions, including nucleophilic substitution and Michael additions, to construct complex heterocycles.

Basic Information

Product Name	1-(2-Bromoethyl)-1H-Pyrrole-2,5-Dione
CAS No.	95212-17-2
Molecular Formula	C6H6BrNO2
Molecular Weight	204.02 g/mol
Synonyms	N-(2-Bromoethyl)maleimide; 2-Bromoethylmaleimide; 1-(2-Bromoethyl)-2,5-pyrroledione; Maleimide, N-(2-bromoethyl)-; N-(2-Bromoethyl)maleimide; 1H-Pyrrole-2,5-dione, 1-(2-bromoethyl)-; 2,5-Pyrroledione, 1-(2-bromoethyl)-
EINECS	Contact for details

Quality Control

Our 1-(2-Bromoethyl)-1H-Pyrrole-2,5-Dione is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability and consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling should be minimized under direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.