Description

2-Thiophenecarboxylic Acid, 2-Chloro-2,3-Dihydro-3-Oxo-, Methyl Ester is a high-purity, specialized heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring both a thiophene ring and a reactive chloro-keto ester moiety, makes it a versatile precursor for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Serves as a crucial building block for creating new generations of herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Used in the synthesis of advanced organic electronic materials, such as novel semiconductors or conductive polymers, due to the electron-rich thiophene core.
• Chemical Biology & Proteomics: Employed as a reactive handle or linker in the design of chemical probes, activity-based protein profiling (ABPP) reagents, and bioconjugation tools.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates under cGMP or non-GMP conditions for client projects.

Basic Information

Product Name	2-Thiophenecarboxylic Acid, 2-Chloro-2,3-Dihydro-3-Oxo-, Methyl Ester
CAS No.	95201-94-8
Molecular Formula	C7H5ClO3S
Molecular Weight	204.63 g/mol
Synonyms	Methyl 2-chloro-3-oxo-2,3-dihydrothiophene-2-carboxylate; 2-Chloro-3-oxo-2,3-dihydrothiophene-2-carboxylic acid methyl ester; Methyl 2-chloro-3-oxo-2,5-dihydrothiophene-2-carboxylate; 2-Chloro-2,3-dihydro-3-oxothiophene-2-carboxylic acid methyl ester; 2-Thiophenecarboxylic acid, 2-chloro-2,3-dihydro-3-oxo-, methyl ester; 95201-94-8; Methyl (2-chloro-3-oxo-2,3-dihydrothiophen-2-yl)formate
EINECS	Contact for details

Quality Control

Our production of 2-Thiophenecarboxylic Acid, 2-Chloro-2,3-Dihydro-3-Oxo-, Methyl Ester adheres to a stringent quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development and commercial projects with material produced under quality agreements and can supply material suitable for research use through to cGMP-grade for advanced clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be moisture-sensitive; keep container tightly sealed under an inert atmosphere if specified for high-purity grades.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.