Description

L-Serine-3,3-D2 is a stable isotope-labeled derivative of the essential amino acid L-serine, specifically deuterated at both 3-position hydrogen atoms. This precise labeling makes it an indispensable tool for advanced research requiring isotopic tracing and internal standards in mass spectrometry. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for metabolic studies, proteomics, and the development of novel diagnostic agents.

Application

• Mass Spectrometry Internal Standards: Used as a quantitative reference standard in LC-MS/MS and GC-MS analyses for accurate measurement of endogenous L-serine levels in complex biological matrices.
• Metabolic Pathway Tracing: Employed in in vitro and in vivo studies to elucidate serine metabolism, glycine synthesis, and one-carbon unit transfer pathways.
• Proteomics & Biomarker Research: Facilitates protein quantification and turnover studies using stable isotope labeling by amino acids in cell culture (SILAC) and related techniques.
• Pharmaceutical Development: Serves as a labeled precursor in the synthesis of deuterated drug candidates to study pharmacokinetics, metabolism, and to potentially enhance drug stability.
• NMR Spectroscopy: Acts as a probe in nuclear magnetic resonance studies to investigate molecular structure and dynamics without signal interference from protons.
• Clinical Diagnostics: Incorporated into assay kits for the precise detection and quantification of serine-related metabolic disorders.

Basic Information

Product Name	L-Serine-3,3-D2
CAS No.	95034-57-4
Molecular Formula	C3H5D2NO3
Molecular Weight	107.11 g/mol
Synonyms	(2S)-2-Azaniumyl-3,3-dideuterio-3-hydroxypropanoate; L-Serine-d2; (S)-2-Amino-3,3-dideuterio-3-hydroxypropanoic Acid; Serine-3,3-d2; Deuterated L-Serine; L-Serine (3,3-d2); (S)-Serine-3,3-d2; Stable Isotope Labeled L-Serine
EINECS	Contact for details

Quality Control

Our L-Serine-3,3-D2 is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity, critical for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity by HPLC, chiral purity, and residual solvent content. We adhere to stringent quality management protocols to guarantee batch-to-batch consistency and reliability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chiral Purity ([α]D)	≥ 99.0% L-isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.