Description

n-Succinimidyl ((Bromoacetyl)Amino)Benzoate is a heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a thiol-reactive bromoacetyl group. This compound is critical for creating stable, site-specific conjugates between proteins, peptides, and other biomolecules, enabling advanced research and development in bioconjugation. It is primarily utilized by researchers and process developers in the pharmaceutical, biotechnology, and diagnostics industries for antibody-drug conjugate (ADC) development, protein labeling, and immobilization strategies.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key chemical bridge for covalently attaching cytotoxic payloads to monoclonal antibodies.
• Protein-Protein Crosslinking: Enables the study of protein interactions and the construction of protein complexes.
• Peptide and Protein Immobilization: Used to tether biomolecules onto solid surfaces (e.g., beads, chips, plates) for assay development and biosensor fabrication.
• Fluorescent or Affinity Probe Conjugation: Facilitates the labeling of proteins with tags for detection, purification, or imaging applications.
• Biomaterial Functionalization: Modifies polymers or nanomaterials with bioactive ligands for targeted drug delivery systems.
• Enzyme Modification: Used to alter enzyme properties or create enzyme conjugates for therapeutic or diagnostic use.

Basic Information

Product Name	n-Succinimidyl ((Bromoacetyl)Amino)Benzoate
CAS No.	94987-16-3
Molecular Formula	C13H11BrN2O5
Molecular Weight	355.14 g/mol
Synonyms	N-Succinimidyl 4-((Bromoacetyl)Amino)Benzoate; S-BAB; 4-((2-Bromoacetyl)Amino)Benzoic Acid N-Hydroxysuccinimide Ester; 4-((Bromoacetyl)Amino)Benzoic Acid Succinimidyl Ester; N-(4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzyl)-2-bromoacetamide; 1-[(4-{[(2-Bromoacetyl)Amino]methyl}phenyl)carbonyl]pyrrolidine-2,5-dione; Bromoacetylaminobenzoyl-N-hydroxysuccinimide Ester; BAB-NHS Ester
EINECS	Contact for details

Quality Control

Our n-Succinimidyl ((Bromoacetyl)Amino)Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep containers in a dry, inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.