Description

(-)-8-(2,3-Dihydroxy-3-Methylbutyl)-5,6,7-Trimethoxy-2H-1-Benzopyran-2-One is a high-purity, optically active coumarin derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical chiral building block or intermediate for developing novel bioactive molecules, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex natural products.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) or anti-inflammatory targets.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Natural Product Synthesis: Serves as an intermediate in the total or semi-synthesis of complex coumarin-based natural products.
• Biochemical Research: Potential use as a probe or inhibitor in enzymatic studies due to its specific stereochemistry and functional groups.
• Process Chemistry Development: Employed in the development and optimization of asymmetric synthetic routes on laboratory and pilot scales.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(-)-8-(2,3-Dihydroxy-3-Methylbutyl)-5,6,7-Trimethoxy-2H-1-Benzopyran-2-One
CAS No.	94977-40-9
Molecular Formula	C₁₉H₂₄O₇
Molecular Weight	364.39 g/mol
Synonyms	(-)-8-(2,3-Dihydroxy-3-methylbutyl)-5,6,7-trimethoxycoumarin; 5,6,7-Trimethoxy-8-(2,3-dihydroxy-3-methylbutyl)coumarin; 8-(2,3-Dihydroxy-3-methylbutyl)-5,6,7-trimethoxy-2H-chromen-2-one; (S)-8-(2,3-Dihydroxy-3-methylbutyl)-5,6,7-trimethoxycoumarin; Optically active trimethoxycoumarin derivative; Coumarin derivative 94977-40-9
EINECS	Contact for details

Quality Control

Our (-)-8-(2,3-Dihydroxy-3-Methylbutyl)-5,6,7-Trimethoxy-2H-1-Benzopyran-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing specific results for assay, optical rotation, and impurity profiles are provided with every shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	Specific range provided on COA
Chiral Purity (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.