Description

(E)-5-(tert-Butyl-Dimethyl-Silanyloxy)-Pent-2-Enoic Acid Ethyl Ester is a high-value, protected synthetic intermediate featuring a silyl ether group and an ethyl ester moiety. This compound is critical for enabling complex multi-step organic syntheses where selective deprotection and further functionalization are required. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing key molecular frameworks.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for prostaglandins, leukotriene analogs, and other bioactive molecules with unsaturated carbon chains.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where its protected hydroxyl group allows for precise structural modifications.
• Organic Synthesis Reagent: Serves as a versatile precursor in academic and industrial laboratories for carbon chain elongation, cross-coupling reactions, and the introduction of the (E)-alkene geometry.
• Flavor & Fragrance Chemistry: Employed as an intermediate in the synthesis of complex esters and unsaturated compounds that contribute to specific olfactory profiles.
• Material Science Research: Acts as a monomer or functionalization agent in the development of specialized polymers and organic electronic materials.
• Process Chemistry Development: Utilized for scaling up synthetic routes from laboratory to pilot plant scale, benefiting from its defined stereochemistry and protective group strategy.

Basic Information

Product Name	(E)-5-(tert-Butyl-Dimethyl-Silanyloxy)-Pent-2-Enoic Acid Ethyl Ester
CAS No.	94844-33-4
Molecular Formula	C13H26O3Si
Molecular Weight	258.43 g/mol
Synonyms	Ethyl (E)-5-[(tert-Butyldimethylsilyl)oxy]-2-pentenoate; (E)-5-[(tert-Butyldimethylsilyl)oxy]-2-pentenoic Acid Ethyl Ester; Ethyl (E)-5-(TBDMSO)-2-pentenoate; TBDMS Protected 5-Hydroxy-2-pentenoic Acid Ethyl Ester; (E)-5-(tert-Butyldimethylsiloxy)pent-2-enoic Acid Ethyl Ester; 94844-33-4; Ethyl (E)-5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-pentenoate
EINECS	Contact for details

Quality Control

Our (E)-5-(tert-Butyl-Dimethyl-Silanyloxy)-Pent-2-Enoic Acid Ethyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity, correct stereochemistry (E-isomer), and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Isomeric Purity (GC/HPLC)	≥ 98.0% (E-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.