Description

Salmeterol Xinafoate CAS NO 94749-08-3 is a long-acting beta2-adrenergic receptor agonist (LABA) pharmaceutical salt, specifically the 1-hydroxy-2-naphthoic acid salt of salmeterol. This compound is a critical active pharmaceutical ingredient (API) used in the formulation of maintenance therapies for chronic respiratory conditions. It is primarily required by pharmaceutical manufacturers and research institutions developing inhalable medications for the management of asthma and chronic obstructive pulmonary disease (COPD).

Application

• Active Pharmaceutical Ingredient (API) in dry powder inhalers (DPIs) and metered-dose inhalers (MDIs) for asthma.
• Formulation Component in combination therapies, often paired with corticosteroids like fluticasone propionate for enhanced efficacy.
• Reference Standard for analytical testing, quality control, and method development in pharmaceutical laboratories.
• Research Chemical for pharmacological studies targeting beta2-adrenergic receptors and bronchodilation mechanisms.
• Pharmaceutical Intermediate for the synthesis of specialized drug delivery systems.
• Regulatory Submission batches for ANDA (Abbreviated New Drug Application) and NDA (New Drug Application) filings.

Basic Information

Product Name	Salmeterol Xinafoate
CAS No.	94749-08-3
Molecular Formula	C36H45NO7
Molecular Weight	603.75 g/mol
Synonyms	Salmeterol 1-Hydroxy-2-naphthoate; Salmeterol Hydroxynaphthoate; Salmeterol Xinafoate USP; GSK-961; GR-33343X; 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol, 1-hydroxy-2-naphthalenecarboxylate (1:1); (±)-Salmeterol Xinafoate
EINECS	Contact for details

Quality Control

Our Salmeterol Xinafoate is manufactured under strict quality management systems. It is typically tested to meet or exceed relevant pharmacopeial standards such as USP (United States Pharmacopeia) and EP (European Pharmacopoeia) monographs. Each batch undergoes rigorous analytical testing including assay, related substances, residual solvents, and microbiological examination. A comprehensive Certificate of Analysis (COA) is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15°C and 25°C (59°F and 77°F). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or a nitrogen atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C
Microbial Enumeration	Complies with EP/USP

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.