Description

2-(Cyclobutylcarbonyl)-1,2,3,4,5,6,7,8-Octahydro-1-[(4-Methoxyphenyl)Methyl]Isoquinoline is a complex organic compound featuring a fused isoquinoline core, a cyclobutyl ketone moiety, and a 4-methoxybenzyl substituent, making it a valuable advanced pharmaceutical intermediate (API). Its sophisticated molecular architecture is specifically engineered for the synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular research. This high-purity building block is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to develop new drug candidates with targeted biological activity.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used as a key scaffold in structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of new drug molecules.
• CNS Drug Discovery: Employed in the research and development of potential therapeutics targeting neurological disorders, given the structural motifs common to neuroactive compounds.
• Process Chemistry & Scale-Up: Provides a defined, high-quality starting material for process optimization and pilot-scale manufacturing under current Good Manufacturing Practice (cGMP) guidelines.
• Contract Research & Development (CRO/CDMO): Supplied to service organizations supporting pharmaceutical companies in their drug discovery and development pipelines.
• Academic Research: Utilized in university and institutional laboratories for fundamental organic synthesis studies and the exploration of new chemical entities.

Basic Information

Product Name	2-(Cyclobutylcarbonyl)-1,2,3,4,5,6,7,8-Octahydro-1-[(4-Methoxyphenyl)Methyl]Isoquinoline
CAS No.	94230-89-4
Molecular Formula	C22H29NO2
Molecular Weight	339.47 g/mol
Synonyms	1-[(4-Methoxyphenyl)methyl]-2-(cyclobutylcarbonyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline; 2-(Cyclobutanecarbonyl)-1-[(4-methoxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline; Octahydro-1-[(4-methoxyphenyl)methyl]-2-isoquinolinecarboxylic acid cyclobutyl ester; CAS 94230-89-4
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality systems suitable for pharmaceutical research. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and spectroscopic identification (NMR, MS, IR). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal quality standards. Specifications can be aligned with the requirements of early-phase drug development under a Quality Agreement.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.