Description

(-)-α-(1,2,3,4,5,6,7,8-Octahydro-1-Isoquinolyl)-p-Cresol is a high-purity, chiral organic compound of significant interest in advanced chemical synthesis. This molecule serves as a critical chiral building block or intermediate for the development of complex, biologically active molecules. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly within medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize biological activity.
• Asymmetric Synthesis: Employed as a precursor or ligand in catalytic asymmetric reactions to induce chirality in target molecules.
• Fine Chemical Production: Serves as a building block for the multi-step synthesis of complex, high-value specialty chemicals.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(-)-α-(1,2,3,4,5,6,7,8-Octahydro-1-Isoquinolyl)-p-Cresol
CAS No.	94006-09-4
Molecular Formula	C16H23NO
Molecular Weight	245.36 g/mol
Synonyms	(-)-α-(1,2,3,4,5,6,7,8-Octahydro-1-isoquinolinyl)-4-methylphenol; (S)-α-(1,2,3,4,5,6,7,8-Octahydroisoquinolin-1-yl)-p-cresol; 4-Methyl-α-[(8S)-1,2,3,4,5,6,7,8-octahydro-1-isoquinolinyl]benzenemethanol; (S)-1-(4-Methylphenyl)-1-(1,2,3,4,5,6,7,8-octahydroisoquinolin-1-yl)methanol; (-)-1-(1,2,3,4,5,6,7,8-Octahydro-1-isoquinolyl)-1-(p-tolyl)methanol
EINECS	Contact for details

Quality Control

Our (-)-α-(1,2,3,4,5,6,7,8-Octahydro-1-Isoquinolyl)-p-Cresol is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.