Description

(-)-3,4,5,6,7,8-Hexahydro-1-[(4-Hydroxyphenyl)Methyl](1H)-Isoquinoline-2-Carbaldehyde is a chiral, complex organic compound featuring a hexahydroisoquinoline core substituted with a 4-hydroxybenzyl group and an aldehyde functionality. This specific stereochemistry and functional group array make it a valuable chiral building block and intermediate for advanced synthetic chemistry. It is primarily utilized by pharmaceutical research and development organizations engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially for central nervous system (CNS) and cardiovascular therapeutics.
• Asymmetric Catalysis Research: Serves as a sophisticated ligand precursor or substrate in the development of new catalytic systems for enantioselective transformations.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its rigid, polycyclic scaffold.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and receptor interactions.
• Process Chemistry Development: Utilized in route scouting and scale-up optimization for the commercial manufacturing of chiral pharmaceuticals.
• Academic & Institutional Research: A valuable compound for synthetic methodology development and teaching advanced organic chemistry concepts.

Basic Information

Item	Details
Product Name	(-)-3,4,5,6,7,8-Hexahydro-1-[(4-Hydroxyphenyl)Methyl](1H)-Isoquinoline-2-Carbaldehyde
CAS No.	94006-07-2
Molecular Formula	C17H21NO2
Molecular Weight	271.36 g/mol
Synonyms	(-)-1-[(4-Hydroxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline-2-carboxaldehyde; (R)-1-((4-Hydroxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline-2-carbaldehyde; 1-[(4-Hydroxyphenyl)methyl]-1,2,3,4,5,6,7,8-octahydroisoquinoline-2-carboxaldehyde (-)-form; 94006-07-2; UNII-9J4K5W888L; 9J4K5W888L; SCHEMBL2180841; DTXSID60672906
EINECS	Contact for details

Quality Control

Our (-)-3,4,5,6,7,8-Hexahydro-1-[(4-Hydroxyphenyl)Methyl](1H)-Isoquinoline-2-Carbaldehyde is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity (HPLC), chiral excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider under an inert atmosphere such as nitrogen or argon. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.