Description

Sodium (5Alpha)-4,5-Epoxy-6-Hydroxy-3-Methoxy-17-Methylmorphinan-6-Sulphonate is a high-purity pharmaceutical intermediate and reference standard of significant importance in the synthesis and analytical control of potent opioid compounds. Its primary value lies in providing a critical, well-characterized building block for advanced pharmaceutical research and development, ensuring precise chemical structure and activity. This compound is essential for manufacturers and research institutions focused on neuropharmacology, analgesic development, and the production of controlled pharmaceutical substances.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of specific opioid analgesics and antagonists.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC/QA) testing via HPLC, LC-MS, or GC-MS.
• Research & Development: Critical for pharmacological studies investigating structure-activity relationships (SAR) within the morphinan class of compounds.
• Impurity Profiling: Serves as a certified reference material to identify and quantify related substances in active pharmaceutical ingredient (API) batches.
• Metabolite Studies: Utilized in the research of drug metabolism and pharmacokinetics (DMPK) for relevant therapeutic agents.
• Regulatory Compliance: Supports regulatory filings by providing a characterized material for stability studies and specification setting.

Basic Information

Product Name	Sodium (5Alpha)-4,5-Epoxy-6-Hydroxy-3-Methoxy-17-Methylmorphinan-6-Sulphonate
CAS No.	93963-26-9
Molecular Formula	C19H22NNaO7S
Molecular Weight	431.44 g/mol
Synonyms	6-O-Sulfonated 14-Hydroxymorphinone Sodium Salt; Sodium 4,5α-Epoxy-6-hydroxy-3-methoxy-17-methylmorphinan-6-sulfonate; 14-Hydroxymorphinone 6-Sulfonate Sodium Salt; Noroxymorphone-6-sulfonate Sodium Salt; 6-Sulfo-oxymorphone Sodium Salt; (5α)-4,5-Epoxy-6-hydroxy-3-methoxy-17-methylmorphinan-6-sulfonic Acid Sodium Salt
EINECS	Contact for details

Quality Control

Our Sodium (5Alpha)-4,5-Epoxy-6-Hydroxy-3-Methoxy-17-Methylmorphinan-6-Sulphonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards suitable for pharmaceutical R&D and reference standard applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.