Description

3,3'-Dichlorobenzidine-D6 (Rings-D6) is a deuterium-labeled internal standard of the aromatic amine 3,3'-dichlorobenzidine, specifically deuterated on the aromatic rings. This compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry analysis, providing a critical reference point for method validation and calibration. It is primarily utilized by analytical chemists and researchers in environmental testing, industrial hygiene monitoring, and forensic toxicology laboratories for the precise detection and quantification of its non-labeled counterpart.

Application

• Internal Standard for LC-MS/MS: Used as a high-purity, isotopically labeled internal standard for the accurate quantification of 3,3'-dichlorobenzidine in complex matrices.
• Environmental Analysis: Critical for trace-level analysis of this regulated aromatic amine in soil, water, and industrial waste samples to meet environmental compliance standards.
• Occupational Safety Monitoring: Enables precise measurement of worker exposure to 3,3'-dichlorobenzidine in air and biological samples (e.g., urine) for occupational health and safety programs.
• Forensic and Clinical Toxicology: Supports method development and validation in forensic investigations and studies concerning the metabolism and biomonitoring of aromatic amines.
• Pharmaceutical Impurity Testing: Serves as a reference standard in the analysis of potential genotoxic impurities (PGIs) in active pharmaceutical ingredients (APIs) and drug products.
• Dye and Pigment Industry Research: Used in analytical methods to study the degradation, metabolism, or environmental fate of benzidine-based dyes and pigments.
• Method Development and Validation: An indispensable tool for developing, optimizing, and validating robust analytical methods in compliance with ICH, FDA, and EPA guidelines.
• Quality Control and Assurance: Employed in the quality control laboratories of chemical manufacturers to ensure the purity of products and monitor for trace contaminants.

Basic Information

Item	Detail
Product Name	3,3'-Dichlorobenzidine-D6 (Rings-D6)
CAS No.	93951-91-8
Molecular Formula	C12H2D6Cl2N2
Molecular Weight	257.18 g/mol (approx.)
Synonyms	3,3'-Dichlorobenzidine-d6; Benzidine-3,3'-dichloro-d6; 3,3'-Dichloro[phenyl-D6]benzidine; Deuterated 3,3'-Dichlorobenzidine; DCB-d6; 4,4'-Diamino-3,3'-dichlorobiphenyl-d6; (3,3'-Dichloro[1,1'-biphenyl]-4,4'-diamine)-d6; 3,3'-Dichlorobiphenyl-4,4'-diamine-d6
EINECS	Contact for details

Quality Control

Every batch of 3,3'-Dichlorobenzidine-D6 (Rings-D6) is manufactured and analyzed under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm deuteration level and chemical identity, ensuring compliance with industry standards for reference materials. Certificates of Analysis (COA) detailing batch-specific purity, isotopic purity (e.g., D-atom %), and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light brown powder or crystals
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Purity (MS)	≥98.0 atom % D (Min. on labeled rings)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.